C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4155 (2006.01) A61K 31/444 (2006.01) A61K 31/497 (2006.01) A61K 31/5355 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) A61P 3/10 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 411/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 419/14 (2006.01)
Patent
CA 2667435
The invention relates to a novel group of compounds of Formula (I) or a salt thereof: wherein R1, A and HET-1 are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK) such as type 2 diabetes. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by GLK using said compounds and methods for preparing compounds of Formula (I).
La présente invention concerne un groupe innovant de composés de formule (I) ou un sel de ceux-ci : dans laquelle R1, A et HET-1 sont tels que décrits dans le mémoire descriptif, lesdits composés pouvant être utilisés pour le traitement ou la prévention d'une maladie ou d'un état médical induit par la glucokinase (GLK) tel que le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, des procédés de traitement de maladies induites par la GLK à l'aide desdits composés et des procédés de préparation des composés de formule (I).
Campbell Leonie
Pike Kurt Gordon
Suleman Abid
Waring Michael James
Astrazeneca Ab
Fetherstonhaugh & Co.
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