A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/403 (2006.01) C07D 209/42 (2006.01) C07D 209/52 (2006.01)
Patent
CA 2317456
A pharmaceutical composition which comprises a compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1, and wherein A and B form an optionally substituted alkylene chain so as to form a ring with the carbon atoms to which they are attached; X is CH2 or SO2, R1 is an optionally substituted aryl or heteroaryl ring; R2 is a specified organic group such as carboxy, and R3 is hydrogen or a specified organic group; in combination with a pharmaceutically acceptable carrier. Certain compounds of formula (I) are novel and are claimed as such.
L'invention porte sur une préparation pharmaceutique comportant un composé de formule (I) ou l'un de ses sels ou esters d'amide pharmacocompatible agissant comme inhibiteur de la protéine dite MCP-1 (protéine chimiotactique vis à vis des monocytes N·1). Dans la formule: A et B forment ensemble une chaîne alkylène facultativement substituée formant un cycle avec les atomes de carbone auxquels ils sont liés; X est CH¿2? ou SO¿2?; R?1¿ est un cycle aryle ou hétéroaryle facultativement substitué; R?2¿ est un groupe organique tel que carboxy; R?3¿ est H, ou un groupe organique spécifique. L'ensemble est associé à un excipient pharmacocompatible. Certains composés de formule (I) sont nouveaux ou revendiqués comme tels.
Barker Andrew John
Faull Alan Wellington
Kettle Jason Grant
Astrazeneca Uk Limited
Smart & Biggar
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