C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/264, 167/274
C07C 217/48 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) C07C 217/08 (2006.01) C07C 217/76 (2006.01) C07C 311/03 (2006.01) C07C 311/35 (2006.01)
Patent
CA 2015188
ABSTRACT CHEMICAL COMPOUNDS The invention relates to compounds of the general formula (I) Image (I) and physiologically acceptable salts and solvates thereof; wherein: R1 and R2 each independently represent a hydrogen atom or a C1-3alkyl group with the proviso that the sum total of carbon atoms in R1 and R2 is not more than 4; X represents a direct bond or a C1-7alkylene, C2-7alkenylene or C2-7alkynylene group and Y represents a direct bond or a C1-6alkylene, C2-6alkenylene or C2-6alkynylene group with the proviso that the sum total of carbon atoms in X and Y is not more than 10; W represents a group Image , Image or Image wherein Z represents a group R3(CH2)q where q is 0, 1 6509/ABS or 2 and R3 is a group R4CONH-, R4NHCONH-, R4R5NSO2NH-, R6SO2NH- or -OH; R4 and R5 each represent a hydrogen atom or a C1-3alkyl group; R6 represents a C1-3alkyl group; R7 represents a chlorine atom or the group -CF3; A represents a straight or branched C1-6alkyl group, a C3-8cycloalkyl group, either of which may be saturated or unsaturated, or a C1-6alkoxy group, with the proviso that the sum total of carbon atoms in A and Y is not less than 5. The invention also relates to processes for making the compounds of formula (I) and to pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) have a stimulant action at .beta.2-adrenoreceptors and are useful in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis. 6509/ABS
Campbell Ian B.
Finch Harry
Judkins Brian D.
Lunts Lawrence H. C.
Mitchell William L.
Campbell Ian B.
Finch Harry
Glaxo Group Limited
Judkins Brian D.
Lunts Lawrence H. C.
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