Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) C12N 9/48 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2286875

The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.

L'invention concerne une construction génique qui code un groupe de ciblage cellulaire et une enzyme hétérologue activatrice de prodrogue, et qui peut être utilisée comme médicament chez un mammifère hôte. Cette construction est capable d'exprimer le groupe de ciblage cellulaire et l'enzyme sous la forme d'un conjugué dans une cellule cible du mammifère hôte. Le conjugué est dirigé de façon à sortir ensuite de la cellule afin de se placer sélectivement au niveau d'un antigène de la surface cellulaire reconnu par le groupe de ciblage cellulaire.

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