Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C12N 9/22 (2006.01) C12N 9/24 (2006.01) C12N 9/48 (2006.01) C12N 9/96 (2006.01) C12N 15/13 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2205091

Improved systems for targetted enzyme prodrug therapy, especially antibody directed enzyme prodrug therapy (ADEPT), in which the enzyme used is a mutated form of a host enzyme in which the natural host enzyme, such as ribonuclease, recognises its natural substrate by an ion pair interaction and this interaction is reversed ("reversed polarity") in the design of mutated enzyme and complementary prodrug.

L'invention concerne des systèmes thérapeutiques améliorés, utilisant un précurseur de médicament et une enzyme ciblée, en particulier une enzyme ciblée grâce à un anticorps. L'enzyme utilisée est une forme mutante d'une enzyme naturelle de l'hôte telle qu'une ribonucléase, qui reconnaît son substrat naturel par interaction d'une paire d'ions, cette interaction étant inversée (polarité inversée) dans le système de l'enzyme mutant - précurseur de médicament complémentaire.

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