Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

07

D

167/223, 260/266

C07D 403/06 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2017020

ABSTRACT PIPERAZINE DERIVATIVES Compounds are disclosed of formula (I) Image wherein R1 represents -COR4, -C02R4, -COCO2R4 or -CONR4Rs (where R4 and RS may be the same or different and represent a hydrogen atom or a Cl_3slkyl group); R2 represents a hydrogen atom or a hydroxy or oxo group, with the proviso that when R1 is -COR4, -CO2R4 or -COCO2R4, R2 is not a hydrogen atom; R3 represents a hydrogen atom or a hydroxy group; X represents a direct bond, -CH2- or -CH20-; Ar represents a substituted phenyl moiety; and physiologically acceptable salts thereof. The compounds are indicated as useful in the treatment of pain. Processes for their preparation and pharmsceutical compositions containing them are also disclosed.

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