Chemical compounds and their uses

Details Chemical compounds and their uses Chemical compounds and their uses

A - Human Necessities

61

K

A61K 31/695 (2006.01) A23K 1/16 (2006.01) A23K 1/18 (2006.01) A61K 31/12 (2006.01) A61K 31/5575 (2006.01) A61P 3/10 (2006.01) A61P 3/14 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 39/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2366877

4- and 5-oxacyclopent-2-en-1-ones have significant activity in activating HSF and in inhibiting NF-~B. They are believed to be useful in treating a wide range of disorders including viral-mediated disorders, bacterial-mediated disorders, disorders mediated by radiation (e.g. by UV-radiation), inflammatory disorders, disorders of the immune system, ischemia, arteriosclerosis, disorders involving cell proliferation (e.g. cancers), disorders involving damage to, or killing of cells (e.g. oxidative cell damage) and diabetes.

Des 4- et 5-oxacyclopent-2-en-1-ones font montre d'un activité significative en activant HSF et en inhibant NF-~B. L'on estime qu'ils se révéleront des plus utiles pour traiter une large gamme d'états pathologiques, au nombre desquels, des états pathologiques provoqués par des virus et par des bactéries, des états pathologiques déclenchés par un rayonnement (par exemple. par le rayonnement ultraviolet), des maladies inflammatoires, des maladies du système immunitaire, l'ischémie, l'artériosclérose, des maladies à prolifération cellulaire (des cancers notamment), des maladies entraînant des dommages aux cellules ou provoquant leur mort (par exemple, altérations cellulaire due à des oxydants) et le diabète.

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