A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/34 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4192 (2006.01) A61K 31/425 (2006.01) A61K 31/433 (2006.01) A61K 31/4453 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2716971
Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of .epsilon.Dengue virus and other flaviviruses.
Uso de compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus Dengue. Particularmente, mediante la interferencia o modulación de varias etapas del ciclo de replicación viral relacionadas con la entrada del virus a las células dianas y el ensamblaje de los viriones progenie. Además, del uso de dichas composiciones farmacéuticas para el tratamiento profiláctico y/o terapéutico de Ia infección causada por los cuatro serotipos del virus de Dengue y por otros flavivirus.
Chinea Santiago Glay
Fleitas Salazar Noralvis
Guirola Cruz Osmany
Huerta Galindo Vivian
Mazola Reyes Yuliet
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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