Chemical compounds, their preparation and use

Details Chemical compounds, their preparation and use Chemical compounds, their preparation and use

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2171940

A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein X is halogen, amino, perhalomethyl, cyano, C1-6-alkoxy, C1-6-alkylthio or C1-6-alkylamino; A is methyl, halomethyl, cyanomethyl, aminomethyl, vinyl, methylthiomethyl or methoxymethyl; R1 is selected from optionally substituted N-bonded heterocyclics. The compounds have been found useful for treating central nervous system ailments.

Composé de la formule (I), ou sel pharmaceutiquement acceptable de ce dernier, formule dans laquelle X représente halogène, amino, perhalométhyle, cyano, C1-6-alcoxy, C1-6-alkylthio ou C1-6-alkylamino; A représente méthyle, halométhyle, cyanométhyle, aminométhyle, vinyle, méthylthiométhyle ou méthoxyméthyle; et R<1> est choisi entre des éléments hétérocycliques à liaison N éventuellement substitués. Il a été découvert que ces composés conviennent au traitement de troubles du système nerveux central.

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