C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/497 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07D 215/38 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2514105
The invention relates to cancer therapy and concerns novel anti-cancer agents exhibiting a highly specific action mechanism. The invention also relates to novel chemical compounds and the therapeutic use thereof in man. The invention describes the preparation of heterocylic diamides of general formula (IB) as highly specific G quadruplex DNA ligands and the use thereof as telomerase inhibitors in man. (IB) nitrogenous aromatic cycle comprising a nitrogen atom in a quaternary form (NR¿3?)p CO distributor (CO)m NR'¿3?)qu X- aromatic or non-aromatic cycle.
La présente invention est relative à la thérapie du cancer et concerne de nouveaux agents anticancéreux ayant un mécanisme d'action bien particulier. Elle concerne aussi de nouveaux composés chimiques ainsi que leur application thérapeutique chez l'homme. La présente invention décrit la préparation de diamides hétérocycliques de formule générale (IB) suivante, comme ligants hautement spécifiques d~AND en G-quadruplexe et leur utilisation comme inhibiteurs de télomérase : (IB) Cycle aromatique azoté possédant un atome d~azote sous forme quaternaire - (NR¿3?)p - CO- répartiteur - (CO)m - (NR~¿3?)q -X- cycle aromatique ou non aromatique.
Belmokhtar Chafke
Bouchard Herve
Caulfield Thomas
Gomez Dennis
Guittat Lionel
Aventis Pharma S.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centre National de La Recherche Scientifique
Commissariat A. L'energie Atomique
Institut Curie
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