Chemical inhibitors of soluble adenylyl cyclase (sac)

A - Human Necessities – 61 – K

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A61K 31/415 (2006.01)

Patent

CA 2553848

The present invention relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject. The method involves administering to a subject an effective amount of a compound disclosed herein that modulates soluble adenylyl cyclase, under conditions effective to treat the disorder mediated by soluble adenylyl cyclase. The present invention also relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject, where the disorder is selected from the group consisting of learning or memory disorders, malaria, fungal infection, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, and peripheral neuropathy. The method involves modulating soluble adenylyl cyclase in the subject. Another aspect of the present invention relates to a method of modulating soluble adenylyl cyclase. The method involves contacting eukaryotic cells with a compound that modulates soluble adenylyl cyclase, under conditions effective to modulate soluble adenylyl cyclase.

La présente invention concerne une méthode de traitement d'un trouble à médiation adénylyle cyclase soluble chez un sujet. Ladite méthode consiste à administrer à un sujet une quantité efficace d'un composé décrit qui module l'adénylyle cyclase soluble, dans des conditions efficaces pour traiter le trouble à médiation adénylyle cyclase soluble. La présente invention concerne également une méthode de traitement d'un trouble à médiation adénylyle cyclase soluble chez un sujet, ce trouble faisant partie du groupe constitué par les troubles de l'apprentissage ou de la mémoire, la malaria, les infections fongiques, les lésions de la moelle épinière, la maladie d'Alzheimer, la sclérose latérale amyotrophique et la neuropathie périphérique. Ladite méthode consiste à moduler l'adénylyle cyclase chez le sujet. Dans un autre aspect, la présente invention concerne un procédé de modulation de l'adénylyle cyclase soluble. Ladite méthode consiste à mettre en contact des cellules eucaryotes avec un composé qui module l'adénylyle cyclase soluble, dans des conditions efficaces pour la modulation de l'adénylyle cyclase soluble.

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