Chemical linkers and cleavable substrates and conjugates...

Details Chemical linkers and cleavable substrates and conjugates... Chemical linkers and cleavable substrates and conjugates...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07H 17/02 (2006.01)

Patent

CA 2674055

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

L'invention concerne des conjugués médicament - ligand et des conjugués médicament - substrat clivable qui sont des cytotoxines puissantes. La divulgation se rapporte également à des compositions contenant les conjugués médicament - ligand, et à des procédés de traitement les utilisant.

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