Chemical linkers with single amino acids and conjugates thereof

Details Chemical linkers with single amino acids and conjugates thereof Chemical linkers with single amino acids and conjugates thereof

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/404 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01) C07D 487/04 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2678514

The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

L'invention concerne des conjugués de médicament-ligand qui sont des cytotoxines puissantes et qui comprennent un liant entre le médicament et le ligand, le liant ayant un acide aminé unique. La description concerne également des compositions contenant les conjugués de médicament-ligand et des procédés de traitement utilisant ceux-ci.

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