Chemical method of labeling proteins with the radionuclides...

Details Chemical method of labeling proteins with the radionuclides... Chemical method of labeling proteins with the radionuclides...

A - Human Necessities

61

K

167/114, 167/47

A61K 49/02 (1980.01)

Patent

CA 1157374

ABSTRACT A novel rapid chemical method of labeling plasma proteins, other compounds and/ or substances containing proteins with radionuclides of Technetium such as 95mTc, 99mTc or 99TC at physiologic pH 7.4 condition, producing a sterile non-pyrogenic ra- dioactive tracer material suitable for biological and medical uses. These radiola- beled protein substances are not denatured by the labeling process but retain their natural physiological and immunological properties. This novel labeling technique provides a simple and rapid means of labeling plasma proteins such as human serum albumin, fibrinogen, antibodies, hormones and enzymes with 95mTc or 99mTc for scin- tigraphic imaging which may allow visualization of thrombi, emboli, myocardial in- farcts, infectious lesions or tumors.

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