A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 11/06 (2006.01)
Patent
CA 2048078
ABSTRACT OF THE DISCLOSURE A composition of matter is provided having the structure I-L where I is an immunoreceptor and L is a bifunctional linker which is attached to a class of chemical moiety on the immunoreceptor through one functional group and has a free second functional group which is a different class of chemical moiety than the class on the immunoreceptor. The I-L composition has monofunctional chemical reactive groups and is characterized by substantially the same specificity and immunoreactivity as the uncomplexed immunoreceptor. Immunoconjugates having the structure I-L-X are also provided where X is a cytotoxic agent. Methods for producing such compositions are also provided. A method for remitting tumor growth is provided where a therapeutic amount of an I-L-X immunoconjugate is administered to a mammal which selectively binds tumor cell antigens through the immunoreceptor.
Brunswick Corporation
Gowling Lafleur Henderson Llp
Research Corporation Technologies Inc.
Wrasidlo Wolfgang A.
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