Chemical process

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/12 (2006.01) C07D 211/22 (2006.01) C07D 239/94 (2006.01)

Patent

CA 2624045

The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4- bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

L'invention concerne des processus chimiques visant la fabrication de certains dérivés de quinazoline ou de leurs sels pharmaceutiquement acceptables. L'invention concerne aussi des processus de fabrication de certains composés intermédiaires utiles dans la fabrication de dérivés de quinazoline et des processus destinés à la fabrication de dérivés de quinazoline utilisant ces composés intermédiaires. Elle concerne notamment des processus chimiques et des composés intermédiaires utiles dans la fabrication du composé 4-(4- bromo-2-fluoroanilino)-6-méthoxy-7-(1-méthylpipéridin-4-ylméthoxy)quinazoline.

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