Chemical process

Details Chemical process Chemical process

C - Chemistry, Metallurgy

07

C

C07C 255/46 (2006.01) C07C 253/30 (2006.01)

Patent

CA 2235043

A process for the preparation of arylcyclobutylnitrile derivatives which involves reaction of a solution of a 1,3-dihalopropane and a cyanobenzyl derivative in a substantially dimethyl sulphoxide-free solvent with a suspension of a base in a substantially dimethyl sulphoxide-free solvent at a temperature of at least 35 ~C.

Ce procédé de préparation de dérivés d'arylcyclobutylnitrile consiste à faire réagir une solution de 1,3-dihalopropane et d'un dérivé de cyanobenzyle dans un solvant sensiblement dépourvu d'oxyde sulfonique de diméthyle, avec une suspension d'une base dans un solvant sensiblement dépourvu d'oxyde sulfonique de diméthyle, à une température d'au moins 35 ·C.

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