Chemical process for the synthesis of macrolide antibiotics

Details Chemical process for the synthesis of macrolide antibiotics Chemical process for the synthesis of macrolide antibiotics

C - Chemistry, Metallurgy

07

H

260/230.3

C07H 17/08 (2006.01)

Patent

CA 1209987

ABSTRACT OF THE DISCLOSURE Fluorinated derivatives of erythromycins A,B,C and D, having antibiotic activity, are prepared, starting from 8,9-anhydroerythromycin 6,9-hemiacetals or their N-oxides, through the reaction with a compound capable of generating electrophilic reactive fluorine, the resulting reaction pro- duct undergoing thereafter a reduction, possibly together with a methylation, to the corresponding (8S)-8-fluoro- erythromycins.

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