Chemical processes

Details Chemical processes Chemical processes

C - Chemistry, Metallurgy

07

C

C07C 253/14 (2006.01) C07C 17/12 (2006.01) C07C 201/12 (2006.01) C07C 205/12 (2006.01) C07C 255/50 (2006.01)

Patent

CA 2344359

(57) Abstract The invention relates to a process for the preparation of a compound of formula (I): wherein, R1 represents C1-4 alkoxy; fluorine, chlorine or bromine; and R2 represents hydrogen or C1-4 alkoxy; which process comprises the reaction of the corresponding orthonitrohalobenzene of formula (II): wherein R1 and R2 are as hereinbefore defined and X represents a fluorine, chlorine or bromine atom, with, when X represents a fluorine atom: a) an alkali metal cyanide, in a non aqueous solvent optionally in the presence of a catalyst; or when X represents a chlorine atom: b) cuprous cyanide and a source of bromide selected from hydrogen bromide, bromine and a tetraalkylammonium bromide; optionally in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of cuprous bromide and a phase transfer catalyst; or d) cuprous cyanide and lithium iodide; or when X represents a bromine atom: e) cuprous cyanide optionally in the presence of a catalyst selected from an alkali metal bromide or an alkaline earth metal bromide; or f) an alkalie metal cyanide in the presence of a catalytic amount of cuprous cyanide and a phase transfer catalyst.

L'invention se rapporte à de nouveaux processus chimiques permettant la préparation des composés représentés par la formule (I), dans laquelle R?1¿ et R?2¿ sont définis dans la description.

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