Chemical sensor for n-acetyl primary aromatic amines

Details Chemical sensor for n-acetyl primary aromatic amines Chemical sensor for n-acetyl primary aromatic amines

C - Chemistry, Metallurgy

12

M

324/23, 150/15.2

C12M 1/40 (2006.01) C12Q 1/00 (2006.01) C12Q 1/34 (2006.01) G01N 27/30 (2006.01) G01N 33/94 (2006.01)

Patent

CA 1249025

A B S T R A C T The present invention is concerned with a chemical sensor, more specifically with a chemical sensor which is capable of detecting the presence of, measuring a quantity of or monitoring the level of N-acetyl primary aromatic amines, such as paracetamol, in whole blood. The specification relates to a method of assay of the type in which an electrode poised at a suitable potential is contacted with a system comprising: a) a sample suspected to contain paracetamol or a derivative thereof, and b) an enzyme capable of catalysing the hydrolysis of an M-acylated primary aromatic amine or a derivative thereof, and, wherein the current flowing in the electrode is a measure of the quantity of hydrolysis products formed and thereby of the concentration of N-acylated primary aromatic amine or derivatives thereof in the sample.

492807

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