C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) G01N 33/58 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2345375
The invention concerns a compound with affinity for a negatively charged phospholipid and a detection molecule, a conjugate and a pharmaceutical composition containing said compound. Generally speaking, the compound of the invention is useful for specific recognition of lipid vectors and can be used for engineering and preparing compounds for identifying and sequestering negatively charged lipids, such as phosphatidyl serine and phosphatidic acid. Said chemical structure many have the construct (I).
La présente invention se rapporte à un composé ayant une affinité pour un phospholipide chargé négativement ainsi qu'à une molécule de détection, à un conjugué et à une composition pharmaceutique comprenant ledit composé. De manière générale, le composé de la présente invention est utile pour la reconnaissance spécifique de vecteurs lipidiques. Il est utilisable pour l'ingénierie et la création de composés de reconnaissance et de séquestration de lipides chargés négativement, tels que la phosphatidyle sérine et l'acide phosphatidique. La structure chimique de la présente invention peut avoir la construction (I).
Cordier-Ochsenbein Francoise
Guerois Raphael
Neumann Jean-Michel
Russo-Marie Francoise
Sanson Alain
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