Chemical synthesis of 6-o-alkyl erythromycin a

Details Chemical synthesis of 6-o-alkyl erythromycin a Chemical synthesis of 6-o-alkyl erythromycin a

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/7048 (2006.01)

Patent

CA 2628019

A process of preparing 6-O-alkyl erythromycin A is provided. The process includes the steps of protecting the oxime hydroxyl of 9-oxime erythromycin A with a benzoyl protecting group, protecting the 2'-hydroxyl group and optionally the 4'--hydroxyl group with an O-protecting group, alkylating the 6-hydroxyl, removing the benzoyl and O-protecting groups and deoximating the 9-oxime.

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