Chemical synthesis of 6-o-alkyl erythromycin c

Details Chemical synthesis of 6-o-alkyl erythromycin c Chemical synthesis of 6-o-alkyl erythromycin c

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01)

Patent

CA 2310003

A process of preparing a 6-O-alkyl derivative of erythromycin C is provided. The process includes the steps of protecting the 2',4"- and 9-oxime hydroxyls with acetyl and ketal protecting groups, alkylating the 6-hydroxyl, removing the protecting groups and deoximating. Intermediates used in the process are also provided.

L'invention concerne un procédé de préparation d'un dérivé 6-O-alkyle de l'érythromycine C. Ce procédé consiste à protéger les 2'-,4''- et 9-oxime hydroxyles avec des groupes protecteurs acétyle et cétal, en alkylant les groupes 6-hydroxyle, en éliminant les groupes protecteurs et en désoximant. L'invention concerne également des intermédiaires utilisés dans le procédé.

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