Chemically activated carboxypolysaccharides and uses

Details Chemically activated carboxypolysaccharides and uses Chemically activated carboxypolysaccharides and uses

A - Human Necessities

61

K

A61K 47/32 (2006.01) A61K 31/715 (2006.01) A61K 38/22 (2006.01) A61K 38/48 (2006.01) C08B 15/00 (2006.01) C08L 1/28 (2006.01)

Patent

CA 2483838

Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of antiadhesion, antithrombogenic, drug delivery and/or hemostatic applications during surgery and pharmacological therapeutics. CPSs derivatized with primary amines can be used alone or in combination with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides) to form materials having improved drug delivery, antiadhesion, and hemostatic uses. Applications include other types of chemical modifications of CPS to provide hydrogen, ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals and other therapeutic or diagnostic purposes.

La présente invention concerne des carboxypolysaccharides (CPS) comprenant de la carboxyméthylcellulose et leurs dérivés qui peuvent être transformés en éponges, gels, membranes, particules et autres formes, destinés à diverses applications anti-adhérentes, antithrombogéniques, d'administration de médicaments et/ou hémostatiques au cours de traitements chirurgicaux et pharmacologiques. Des CPS dérivés à l'aide d'amines primaires peuvent être utilisés seuls ou en combinaison avec du poly(éthylène glycol) et des poly(éthylène oxydes) et d'autres poly(alkylène oxydes) afin de former des matières présentant des utilisations d'administration de médicaments, d'anti-adhérence et d'hémostase améliorées. Parmi les applications, on trouve d'autres types de modifications chimiques de CPS permettant des interactions hydrogène, ionique, de Van der Walls et/ou une liaison covalente avec des médicaments, des agents biologiques et d'autres applications thérapeutiques ou diagnostiques.

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