Chemically induced intracellular hyperthermia

Details Chemically induced intracellular hyperthermia Chemically induced intracellular hyperthermia

A - Human Necessities

61

K

A61K 31/06 (2006.01) A61K 31/00 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2337690

An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia-inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation.

L'invention concerne des agents pharmacologiques thérapeutiques et des procédés pouvant induire chimiquement une hyperthermie intracellulaire et/ou des radicaux libres pour diagnostiquer ou traiter des infections, des malignités ou d'autres troubles médicaux. L'invention concerne également un procédé et une composition permettant de diagnostiquer ou tuer des cellules cancéreuses, ou d'inactiver des agents pathogènes bactériens, parasitiques, fongiques ou viraux sensibles par génération chimique de chaleur, et/ou des radicaux libres et/ou déterminants immunogènes pouvant être induits par l'hyperthermie, au moyen d'agents mitochondriaux découplants, notamment 2,4 dinitrophénol, et leurs conjugués, seuls ou en combinaison avec d'autres médicaments, hormones, cytokines, et par rayonnement.

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