Chemically inert molecular alkane or oxaalkane-tags and...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 69/92 (2006.01) C07B 61/00 (2006.01) C07C 19/08 (2006.01) C07C 65/21 (2006.01) C07C 69/78 (2006.01) C07C 245/14 (2006.01) G01N 33/532 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2482987

A method for identifying a solid support in combinatorial synthesis or determining the structure of a compound in combinatorial synthesis. The method involves attaching, detaching and identifying at least one tag by detaching the tag from the solid support and reacting the detached tag with a fluoroalkanoyl acid or its alcohol-reactive equivalent. A preferred linker/tag is of formula -C(=O)C6H3(OCH3)-OR1 in which R1 is C13 to C33 alkane or ether.

L'invention concerne une méthode destinée à identifier un support solide dans une synthèse combinatoire ou à déterminer la structure d'un composé dans une synthèse combinatoire. Cette méthode consiste à attacher, détacher et identifier au moins une étiquette en détachant l'étiquette du support solide et en faisant réagir l'étiquette détachée avec un acide fluoroalcanoyle ou son équivalent réactif à un alcool. Un lieur ou une étiquette préféré(e) est représenté(e) par la formule (I), dans laquelle R<1> est alcane C13-C33.

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