Chemically modified enzymes with multiple charged variants

Details Chemically modified enzymes with multiple charged variants Chemically modified enzymes with multiple charged variants

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C12N 9/50 (2006.01) C12N 9/54 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) C12Q 1/34 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2353789

This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.

La présente invention concerne des enzymes modifiées comprenant un ou plusieurs résidus d'acides aminés remplacés par des résidus de cystéine, ces derniers étant modifiés en remplaçant l'hydrogène thiol par un substituent présentant une chaîne latérale thiolique qui comprend une fraction à charge multiple. Ces enzymes présentent une interaction et/ou spécificité et/ou activité améliorée avec les substrats chargés.

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