Chemically-modified human growth hormone conjugates

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/61 (2006.01) A61K 38/27 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2467731

The present invention provides a chemically modified human Growth Hormone (hGH) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activity than that of the unmodified hGH, enabling reduced dose and scheduling opportunities.

La présente invention concerne une hormone de croissance humaine (hGH) chimiquement modifiée obtenue par la liaison d'un polymère soluble dans l'eau à une protéine. La protéine chimiquement modifiée selon la présente invention peut avoir une activité hGH de durée plus longue que celle de la hGH modifiée, ce qui permet d'obtenir une dose réduite et des opportunités de calendrier.

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