Chemically-modified human growth hormone receptor antagonist...

Details Chemically-modified human growth hormone receptor antagonist... Chemically-modified human growth hormone receptor antagonist...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 5/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2553899

The present invention provides a chemically modified human Growth Hormone (hGH) receptor antagonists prepared by attaching a single polyethylene glycol moiety to the N-terminus. The chemically-modified protein according to the present invention have decreased PEGylation heterogeneity and which may also have increased binding affinity.

L'invention concerne des antagonistes du récepteur de l'hormone de croissance (hGH) humaine chimiquement modifiés préparés par fixation d'une fraction simple de polyéthylèneglycol au terminal N. La protéine chimiquement modifiée selon l'invention présente une hétérogénéité de PEGylation réduite et peut également présenter une affinité de liaison accrue.

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