C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.1, 167/1
C07K 14/55 (2006.01) C07K 1/107 (2006.01) C07K 14/56 (2006.01) C07K 14/57 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1255588
Abstract of the Disclosure The invention provides chemically modified lymphokines having R?-O-CH2CH2-?n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the same. The chemically modified lymphokines according to the invention can be produced by reacting a lymphokine with an aldehyde of the formula R?-O-CH2CH2-?n-1O-CH2CHO wherein R and n are as defined above, in the presence of a reducing agent. The chemically modified lymphokines according to the invention are useful as drugs.
475743
Fujino Masahiko
Nishimura Osamu
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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