Chemically modified nucleic acids and methods for coupling...

Details Chemically modified nucleic acids and methods for coupling... Chemically modified nucleic acids and methods for coupling...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07B 61/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2326684

The invention relates to novel chemically modified nucleic acids with enhanced lability towards solid supports, such as glass. These modified nucleic acids can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified nucleic acids as well as methods for preparing these microarrays are also useful.

L'invention concerne de nouveaux acides nucléiques modifiés chimiquement présentant une labilité améliorée pour des supports solides, tels que le verre. Ces acides nucléiques modifiés se fixent aisément à des supports solides, tels qu'une surface de verre, sans dérivatisation préalable de ladite surface. L'invention concerne en outre des micro-réseaux haute densité obtenus à partir desdits acides nucléiques ainsi que des procédés de préparation desdits micro-réseaux.

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