C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2166079
A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the mutagen is brought into proximity with the target molecule and causes a mutation at a specific site therein. The mutation activates, inactivates or alters the activity and function of the target molecule.
Oligonucléotide mutagène triplet et son mode d'utilisation. Ledit oligonucléotide subit une modification chimique pour incorporer un mutagène et former une molécule d'acide nucléique à brin triple avec un segment donné d'ADN d'une molécule cible d'ADN. Lors de la formation du triplet, le mutagène s'approche de la molécule cible et y produit une mutation en un site déterminé. La mutation active ou désactive la molécule cible, ou en modifie l'activité et le fonctionnement.
Glazer Peter
Havre Pamela A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Yale University
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