Chemically modified oligonucleotides for use in modulating...

Details Chemically modified oligonucleotides for use in modulating... Chemically modified oligonucleotides for use in modulating...

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2618995

This invention relates generally to chemically modified oligonuceotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonuceotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides.

La présente invention concerne de façon générale des oligonucléotides chimiquement modifiés pouvant être employés dans la modulation de l'expression de micro-ARN et de pré-micro-ARN. Plus particulièrement, la présente invention concerne des oligonucléotides chimiquement modifiés monobrin permettant d'inhiber l'expression de micro-ARN et de pré-micro-ARN, ainsi que des méthodes de fabrication et d'emploi des oligonucléotides modifiés.

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