Chemically modified peptides with improved immunogenicity

Details Chemically modified peptides with improved immunogenicity Chemically modified peptides with improved immunogenicity

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/07 (2006.01) A61K 39/08 (2006.01)

Patent

CA 2693958

Che invention provides processes for improving the ability of a peptide to stimulate an immune response, comprising exposing the peptide to a chemical modifying agent. It further provides compositions comprising an antigenic peptide, wherein the peptide has been treated with a chemical modifying agent to improve its ability to stimulate an immune response. It also provides methods of stimulating an immune response in a mammal, comprising administering to the mammal an effective amount of a vaccine.

L'invention concerne des procédés permettant d'améliorer l'aptitude d'un peptide à stimuler une réponse immunitaire, comprenant l'exposition du peptide à l'action d'un agent de modification chimique. L'invention concerne en outre des compositions comprenant un peptide antigénique, le peptide ayant été traité par un agent de modification chimique pour améliorer son aptitude à stimuler une réponse immunitaire. L'invention concerne également des procédés de stimulation d'une réponse immunitaire chez un mammifère, comprenant l'administration audit mammifère d'une quantité efficace d'un vaccin.

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