Chemically modified protein

Details Chemically modified protein Chemically modified protein

C - Chemistry, Metallurgy

07

K

530/15.04

C07K 1/107 (2006.01) A61K 38/16 (2006.01)

Patent

CA 1294088

ABSTRACT OF THE DISCLOSURE An islet-activating protein produced by bacteria belonging to the genus Bordetella is chemically modified with p~lyethylene glycol moiety of the formula: -O-(-CH2CH2O-)?R (wherein R is a protective group for hydroxyl and ? is an integer of about 7 to 700), the polyethylene glycol moiety being bound to a primary amino group of the islet-activating protein. The chemically modified protein has a strong islet-activating activity and has lower side effects than non-modified IAP, so that it may be employed as a preventive and therapeutic drug for diabetes.

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