Chemically modified protein and production thereof

Details Chemically modified protein and production thereof Chemically modified protein and production thereof

C - Chemistry, Metallurgy

12

N

167/103, 530/13,

C12N 9/00 (2006.01) C07K 1/107 (2006.01) C07K 14/55 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1336967

Disclosed are chemically modified proteins having a group of the formula: Image (wherein R represents a hydrogen atom or a lower alkyl, m represents a positive integer and n represents an integer of 1 to 4), the group being bonded to at least one primary amino group of the protein. The chemically modified proteins can be produced by reacting a protein with an imidoester of the formula: Image (wherein R, n and m are as defined above and R' represents an ester forming group). The chemically modified proteins are useful as drugs, among others.

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