Chemically modified small molecules

Details Chemically modified small molecules Chemically modified small molecules

C - Chemistry, Metallurgy

07

C

C07C 43/11 (2006.01) A61K 47/48 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2758460

The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water- soluble oligomer.

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