Chemically-stabilized chlorite solutions for treating cancer...

A - Human Necessities – 61 – K

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A61K 33/40 (2006.01) A61K 33/20 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2382293

Methods of using a stabilized chlorite matrix to modulate immune responses and treat cancer are disclosed. The stabilized chlorite matrix, when administered to a mammal in need thereof, can activate immune cells in a manner similar to interferon gamma but does not effect the production of inflammatory and shock related cytokines like tumor necrosis alpha. The stabilized chlorite matrix also upregulates the expression of the DCC protein in macrophages, a protein whose expression is related to neoplastic transformation. By activating macrophages, the stabilized chlorite matrix therefore is useful as an immunomodulatory agent and in treating cancer.

L'invention concerne des méthodes d'utilisation d'une matrice de chlorite stabilisé, destinée à moduler des réponses immunes et à traiter le cancer. Cette matrice de chlorite stabilisé, lorsqu'on l'administre à un mammifère nécessitant un tel traitement, peut activer des cellules immunes de manière similaire à l'interféron gamma, mais elle ne produit pas de cytokines inflammatoires ou associées au stress, comme le facteur de nécrose tumorale alpha. Cette matrice de chlorite stabilisé régule également en amont l'expression de la protéine DCC dans des macrophages, protéine dont l'expression est associée à la transformation néoplasique. En activant les macrophages, la matrice de chlorite stabilisé est donc utile en tant qu'agent immunomodulateur et dans le traitement du cancer.

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