Chemically stable compositions of 4-hydroxy tamoxifen

A - Human Necessities – 61 – K

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Details

A61K 31/138 (2006.01) A61K 9/08 (2006.01) A61K 47/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2557806

A class of chemically stable 4-hydroxy tamoxifen compositions is characterized by roughly equal amounts of the Z-4-hydroxy tamoxifen and E-4-hydroxy tamoxifen isomers, such that the potency of the compositions is not affected adversely by the isomerization that occurs between these two forms. The inventive compositions are useful for preventing or for treating medical conditions.

La présente invention concerne une classe de compositions chimiquement stables à base de 4-hydroxy tamoxifène, caractérisées par des quantités presque égales d'isomères Z-4-hydroxy tamoxifène et E-4-hydroxy tamoxifène, de telle sorte que la puissance de ces compositions n'est pas affectée négativement par l'isomérisation déclenchée entre ces deux formes. Les compositions décrites dans cette invention sont utiles pour prévenir ou pour traiter des états pathologiques.

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