G - Physics – 01 – N
Patent
G - Physics
01
N
150/19, 150/3.1
G01N 21/76 (2006.01) G01N 33/00 (2006.01) G01N 33/52 (2006.01) G01N 33/68 (2006.01) G01N 33/84 (2006.01)
Patent
CA 1290670
ABSTRACT OF THE DISCLOSURE: A chemiluminescence method for assaying compounds containing primary amino groups using l-cyano-2-substituted benz[f]- or naphth[f]-isoindole fluorescers is disclosed. The l-cyano-2-substituted benz[f]- or naphth[f]-isoindole (CBI or CNI) is formed by reacting a compound containing a primary amino group with naphthalene-2-3-dicarboxaldehyde or anthracene-2,3- dicarboxaldehyde in the presence of cyanide ion. The reaction product of hydrogen peroxide with an oxalate ester is then combined with the CaI or CNI to form an analyte which exhibits chemiluminescence. A detector is used to measure the chemilumi- nescence emission from the chemiluminescence derivatized analytes. Compounds containing primary amino groups which may be assayed according to the present invention include primary amines, amino acids, peptides and catechloamines. The method can also be adapted to the analysis of trace amounts of cyanide ion and hydrogen peroxide. The isoindole fluorescers include compounds of the formula: Image
531493
Carlson Robert G.
Givens Richard S.
Higuchi Takeru
Kawasaki Takao
Matuszewski Bogdan
Carlson Robert G.
Givens Richard S.
Higuchi Takeru
Kawasaki Takao
Matuszewski Bogdan
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