C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
150/1, 260/1, 26
C07D 237/32 (2006.01) C07D 209/48 (2006.01) C07J 43/00 (2006.01) G01N 33/533 (2006.01)
Patent
CA 1146937
ABSTRACT OF THE DISCLOSURE Chemiluminescent-labeled conjugates of the formula: Chemi-R-L wherein Chemi represents a moiety which is capable of under- going a change in chemical structure with the production of light, R is a linking group, and L is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an antibody, or a binding analog thereof. The chemilumin- escent moiety may be luminol, isoluminol, pyrogallol or luci- ferin. Preferred labeled conjugates are of the formula: Image wherein one of R1 and R2 is hydrogen and the other is -NR3R4; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R4 is Image wherein ? = 1-3 and L(CO? is the ligand or analog bound through an amide bond. Intermediates produces in the synthesis of such preferred conjugates are also disclosed.
327349
Boguslaski Robert C.
Carrico Robert J.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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