Chemo-enzymatic process for preparing escitalopram

Details Chemo-enzymatic process for preparing escitalopram Chemo-enzymatic process for preparing escitalopram

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01)

Patent

CA 2561888

A process is described for preparing the intermediate for synthesizing escitalopram and the pharmaceutically acceptable salts thereof from 4-(4- dimethylamino)-1-(4~-fluorophenyl)-1-(hydroxybutyl)-3(acyloxymethyl) benzonitrile which, by means of enzymatic enantiomeric resolution, is synthesized into one of the enantiomers thereof.

L'invention concerne un procédé de préparation d'un intermédiaire pour la synthèse d'escitalopram et de sels acceptables sur le plan pharmaceutique de ce dernier à partir de 4-(4-diméthylamino)-1-(4'fluorophényl)-1-(hydroxybutyl)-3-(acyloxyméthyl) benzonitrile qui, par résolution enzymatique énantiomère, est synthétisé en un des énantiomères de celui-ci.

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