Chemo-mechanical expansion delivery system

Details Chemo-mechanical expansion delivery system Chemo-mechanical expansion delivery system

A - Human Necessities

61

J

A61J 3/07 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 47/38 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2230656

System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.

Système de distribution d'une substance biologiquement active dans un milieu. On décrit un contenant à un seul élément ou à deux éléments jumeaux définissant un premier et un deuxième compartiment. Le contenant a des pores au moins sur une partie qui définit le premier compartiment, lequel contient un réseau en gel de polymère qui subit une expansion de volume suite à une modification d'état dans le milieu biologique. Le deuxième compartiment renferme une quantité efficace de composés biologiquement actifs et peut comporter au moins une communication avec le milieu biologique. La distribution du ou des médicaments est amorcée et se poursuit uniquement lorsque l'état ou le seuil approprié du milieu est rencontré, moyennant quoi l'expansion du volume du réseau en gel de polymère induit l'introduction du composé biologiquement actif dans le milieu biologique.

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