Chemo-sensitivity assays using tumor cells exhibiting...

G - Physics – 01 – N

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G01N 33/574 (2006.01)

Patent

CA 2620936

The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to detect phenotypic and genotypic drift and for predicting chemotherapeutic response of patient tumor cells to at least one therapeutic agent. The assays, methods, tools and systems discussed herein also represent an improved and unified system for monitoring and for screening multiple pharmaceutical agents for efficacy and long term effect as to a specific patient.

Les tests, méthodes, instruments et systèmes faisant l'objet de cette invention, représentent un système amélioré et unifié permettant de surveiller la progression d'une tumeur maligne chez un patient individuel. Les tests, procédés, instruments et systèmes décrits représentent un système amélioré et unifié permettant la surveillance et l'identification de marqueurs cellulaires et sécrétés, et le criblage des cellules afin de détecter la dérive phénotypique et génotypique et de prédire la réponse chimiothérapeutiques des cellules tumorales du patient à au moins un agent thérapeutique. Ces tests, ces méthodes, ces instruments, et ces systèmes représentent en outre un système amélioré et unifié permettant le contrôle et la sélection d'une pluralité d'agents pharmaceutiques en fonction de leur efficacité et de leur effet à long terme sur un patient spécifique.

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