Chemokine alpha 2

Details Chemokine alpha 2 Chemokine alpha 2

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2249997

Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin- independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.

L'invention concerne: des polypeptides du chimiokine humain Alpha-2 et du codage ADN (ARN) de ces cytokines chimiotactiques, ainsi que d'un procédé de production de ces polypeptides utilisant les techniques de la recombinaison; des méthodes d'utilisation de ces cytokines chimiotactiques pour traiter la leucémie, les tumeurs, les infections chroniques, la maladie auto-immune, les troubles d'orde fibreux, le psoriasis, et pour guérir les blessures; des antagonistes de ces cytokines chimiotactiques et leur utilisation dans le traitement thérapeutique de l'arthrite rhumatoïde, de la maladie auto-immune, des maladies chroniques, infectieuses ou inflammatoires graves, des réactions allergiques, de la fièvre non liée à la prostaglandine et de l'insuffisance médullaire. L'invention concerne également des méthodes diagnostiques permettant de détecter des maladies liées aux mutations dans les séquences nucléotidiques et à des concentrations modifiées des polypeptides, ainsi que des méthodes diagnostiques permettant de détecter des mutations dans les polynucléotides codant les cytokines chimiotactiques et des niveaux modifiés de polypeptides chez un hôte.

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