Chemokine beta-15

Details Chemokine beta-15 Chemokine beta-15

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2258507

The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine .beta.-15 protein. Chemokine .beta.-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.

Membre de la famille des protéines chemokines CC humaines, et plus particulièrement molécules isolées d'acide nucléique codant la protéine chemokine .beta.-15. L'invention porte également sur des polypeptides chemokine .beta.-15 et sur des méthodes diagnostiques pour détecter les dysfonctionnements du thymus et sur des méthodes thérapeutiques pour moduler la prolifération et la différenciation des cellules de la moelle osseuse.

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