Chemokine beta-6

Details Chemokine beta-6 Chemokine beta-6

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/52 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/84 (2006.01) G01N 33/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2285622

Human chemokine .beta.-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine .beta.-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asthma, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine .beta.-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.

L'invention porte sur des polypeptides agonistes et antagonistes de la chémokine beta -6 humaine, sur l'ADN codant pour lesdits polypeptides et sur un procédé d'obtention de ces mêmes polypeptides par des techniques de recombinaison. Lesdits antagonistes servent à traiter la polyarthrite rhumatoïde l'inflammation des poumons, les allergies, l'asthme, les maladies infectieuses et à prévenir les inflammations et l'athérosclérose, tandis que les susdits agonistes peuvent être employés chez des patients subissant une chimiothérapie comme protecteur de la moelle.

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