C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/17 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C12N 15/00 (2006.01) C12N 15/03 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2350771
The present invention relates to deletion and substitution mutant polypeptides of human chemokine .beta.-7 (Ck.beta.-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck.beta.-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck.beta.-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.
Polypeptides mutants, par suppression ou substitution, de la chémokine .beta.-7 (Ck.beta.-7) humaine, ainsi que molécules d'acide nucléique qui codent ces polypeptides et procédés de production desdits polypeptides à l'aide de techniques de recombinaison. Selon un aspect, la présente invention concerne également les utilisations de formes pleine longueur et matures de Ck.beta.-7, ainsi que des mutants par suppression et substitution, dans des méthodes de traitement médicales. En particulier, les polypeptides Ck.beta.-7 décrits peuvent être employés pour traiter toute une gamme d'états pathologiques, dont la polyarthrite rhumatoïde, les inflammations, les maladies respiratoires, les allergies, et les réactions allergiques induites par IgE.
Graham Gerard John
Li Haodong
Nibbs Robert John Benjamin
Patel Vikram
Ruben Steven M.
Beatson Institute For Cancer Research
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
LandOfFree
Chemokine .beta.-7 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemokine .beta.-7, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemokine .beta.-7 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1411447