C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/065 (2006.01) A61K 38/16 (2006.01) C12N 15/39 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2578904
Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumour necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in bloking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.
La présente invention concerne un domaine C-terminal (C-terminal domain / CTD) de récepteurs de facteurs de nécrose tumorale virale (viral tumour necrosis factor receptors / vTNFRs), des homologues CrmB, CrmD ou CTD (CTD1, CTD2 et CTD3) provenant du poxvirus et leurs homologues fonctionnels comprenant des dérivés et des fragments, à utiliser pour réaliser la liaison de chimiokines et de leurs homologues et/ou pour améliorer les propriétés immuno-modulatoires des TNFRs ou pour bloquer la liaison de chimiokines à leurs récepteurs de surface cellulaire correspondants et/ou moduler l'activité biologique de chimiokines.
Alcami Pertejo Antonio
Alejo Herberg Ali
Ho Yin
Ruiz-Arguello Maria Begona
Saraiva Margarida
Alcami Pertejo Antonio
Gowling Lafleur Henderson Llp
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