Chemokine-binding protein thap1, methods and use thereof

Details Chemokine-binding protein thap1, methods and use thereof Chemokine-binding protein thap1, methods and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2529814

Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine- binding domain of a THAP-family polypeptide. Also disclosed are methods of binding chemokines, inhibiting the activity of chemokines, detecting chemokines, and reducing the symptoms associated with a chemokine mediated or influenced condition by contacting the chemokine with an agent that includes a polypeptide comprising a chemokine binding domain of a THAP-family polypeptide.

L'invention concerne des domaines fixateurs des chimiokines de polypeptides de la famille des THAP, ainsi que des compositions renfermant un polypeptide comprenant un domaine fixateur des chimiokines d'un polypeptide de la famille des THAP. Elle concerne également des méthodes pour fixer les chimiokines, inhiber leur activité, les détecter, et réduire les symptômes associés à une pathologie médiée ou influencée par les chimiokines en mettant ces dernières en contact avec un agent contenant un polypeptide comportant un domaine fixateur des chimiokines d'un polypeptide de la famille des THAP.

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